“The Burden of the Mystery”: Keats’s Reflections on Religion and Death

Long time has passed since John Keats died but still his literary heritage continues to inspire numerous researchers. The reason of such interest in Keats’s personality is the universality of themes that he encapsulated in his poetry. Keats’s works incorporate the fears and strivings to grasp all mysteries of the universe illustrating impermanence of life and strength of human spirit. Especially the poet explored the topics of death and religion creating his works “On Death”, “To Autumn”, “Written in Disgust of Vulgar Superstition”, “God of Meridian”, Why Did I Laugh Tonight?” and “When I Have Fears That I May Cease to be”. Keats is also known for his progressive ideas of personality and process of individuation, which can be compared to the works of Carl Jung. The current research implements analytical analysis of several poems in the implementation of the Jung’s theory of individuality in order to explore the topics of religion and death more accurately. The study aimed to reveal the connection between the ideas applied in Keats’s works and Jung’s framework of individuation. The research made the conclusion that Keats was ahead of his contemporaries fostering the ideas of freedom of the individual from the restrictions of religious superstitions and promoting the power of spirituality and intellectual development

Otrouha: A Corpus of Arabic ETDs and a Framework for Automatic Subject Classification

Although the Arabic language is spoken by more than 300 million people and is one of the six official languages of the United Nations (UN), there has been less research done on Arabic text data (compared to English) in the realm of machine learning, especially in text classification. In the past decade, Arabic data such as news, tweets, etc. have begun to receive some attention. Although automatic text classification plays an important role in improving the browsability and accessibility of data, Electronic Theses and Dissertations (ETDs) have not received their fair share of attention, in spite of the huge number of benefits they provide to students, universities, and future generations of scholars. There are two main roadblocks to performing automatic subject classification on Arabic ETDs. The first is the unavailability of a public corpus of Arabic ETDs. The second is the linguistic complexity of the Arabic language; that complexity is particularly evident in academic documents such as ETDs. To address these roadblocks, this paper presents Otrouha, a framework for automatic subject classification of Arabic ETDs, which has two main goals. The first is building a Corpus of Arabic ETDs and their key metadata such as abstracts, keywords, and title to pave the way for more exploratory research on this valuable genre of data. The second is to provide a framework for automatic subject classification of Arabic ETDs through different classification models that use classical machine learning as well as deep learning techniques. The first goal is aided by searching the AskZad Digital Library, which is part of the Saudi Digital Library (SDL). AskZad provides other key metadata of Arabic ETDs, such as abstract, title, and keywords. The current search results consist of abstracts of Arabic ETDs. This raw data then undergoes a pre-processing phase that includes stop word removal using the Natural Language Tool Kit (NLTK), and word lemmatization using the Farasa API. To date, abstracts of 518 ETDs across 12 subjects have been collected. For the second goal, the preliminary results show that among the machine learning models, binary classification (one-vs.-all) performed better than multiclass classification. The maximum per subject accuracy is 95%, with an average accuracy of 68% across all subjects. It is noteworthy that the binary classification model performed better for some categories than others. For example, Applied Science and Technology shows 95% accuracy, while the category of Administration shows 36%. Deep learning models resulted in higher accuracy but lower F-measure; their overall performance is lower than machine learning models. This may be due to the small size of the dataset as well as the imbalance in the number of documents per category. Work to collect additional ETDs will be aided by collaborative contributions of data from additional sources

IRRITANT CONTACT DERMATITIS ON HANDS AND DIAGNOSIS OF IT: A REVIEW

Hand hygiene (HH) is the single most important procedure that can be followed by healthcare workers (HCWs) to reduce the risk of spreading healthcare-associated infections. The irritating contact dermatitis (ICD) that occurs due to the rehashed presentation of HH products and technique is one reason often referred to for resistance. HH is the most vital method that can be followed by HCWs to reduce the possibility of spreading of infection in human being, followed by50% of HCWs. Limited researches are published related to different features of irritant contact disorders among HCWs. This study concentrates manly on the clinical application of irritant contact dermatitis on hands and its diagnosis based on an extensive research review process. It can be concluded from this review that by proper adherence and compliance to necessary HH techniques lead to skin damage and higher pathogen load. Therefore, it is important that HCWs should appreciate this concept and are given methods or tactics of expertise to avoid skin irritation and damage. Inability to provide proper policies, practices and guidelines to these workers may lead to adherence in case of an ICD appearance

Myopia progression in school children with prolonged screen time during the coronavirus disease confinement

Background: Myopia, the most common refractive error, is a global public health problem with substantial visual impairment if left untreated. Several studies have investigated the association between increased near-work and restricted outdoor activities in children with myopia; however, such studies in children without myopia are scarce. We aimed to monitor the effect of the coronavirus disease-2019 (COVID-19) home confinement and mandatory virtual learning on myopic progression among myopic and non-myopic school-aged children. Methods: We conducted a retrospective chart review of children aged 6 – 12 years attending regular visits to the pediatric ophthalmology clinic in a tertiary eye hospital in Eastern Province, Saudi Arabia. Cycloplegic refraction was determined from three visits at least six months apart: two visits before the start of the COVID-19 pandemic and one during the COVID-19 home confinement. Parents were asked about the time spent in near-work and outdoor activities, the devices used during virtual learning, and the demographic characteristics of the children. Statistical analyses were conducted to compare myopia progression before and during the COVID-19 home confinement. Results: A total of 160 eyes of 80 children were analyzed. The boy (n = 46) to girl (n = 34) ratio was 1.4:1. The hyperopia (n = 131 eyes) to myopia (n = 29 eyes) ratio was 4.5:1. Most eyes exhibited a hyperopic shift before the confinement; however, all eyes displayed a myopic shift during the confinement. When comparing both eyes of the same individual, the more myopic or less hyperopic eye in the same child had a significantly greater myopic shift than the fellow eye (both P < 0.05). Children who used tablets showed a significant myopic shift (P < 0.05). Likewise, children in both age categories (less than or equal to 8 and > 8 years), boys, those living in an apartment, and those having parents with bachelor’s degrees experienced a significant myopic shift during COVID-19 home confinement compared to before (all P < 0.05). The mean myopic shift was greater in children aged > 8 years than in those aged less than or equal to 8 years. Children with and without a family history of myopia had a myopic shift in the mean spherical equivalent during COVID-19 home confinement; however, that of children with no family history was statistically significant (P < 0.05). Conclusions: Progression of myopia accelerated in children during the COVID-19 pandemic. Excessive time spent on digital screen devices at near distances is considered a substantial environmental contributor to myopic shift in children. Further multicenter studies with extended follow-up periods are needed to assess the factors contributing to myopic progression in our population

Innovative Approaches To Nursing Administration Education; A Systematic Review Based Study

Background: Nursing administration education plays a crucial role in the development of skilled leaders in the ever-evolving healthcare industry. To meet the current challenges in healthcare, it is crucial to employ innovative pedagogical approaches. These approaches include the integration of virtual reality simulations, fostering interdisciplinary collaboration, utilizing real-world case studies, implementing telehealth platforms, and establishing mentorship programs. Addressing this need for forward-thinking nursing administrators is imperative. Aim: This study comprehensively examines the impact of these innovative strategies on nursing administration education. It assesses how their integration enhances decision-making, communication, strategic thinking, technological proficiency, and leadership skills among students. The goal is to illuminate the potential of these approaches in molding skilled healthcare leaders. Method: A mixed-methods approach is utilized. Qualitative interviews with nursing administration students exposed to innovative approaches provide insights. Thematic analysis is employed to extract meaningful patterns, capturing both subjective experiences and skill development outcomes. Results: Findings highlight the transformative potential of innovative approaches in nursing administration education. Virtual reality simulations enhance decision-making, interdisciplinary collaboration fosters effective communication and teamwork, real-world case studies cultivate strategic thinking, telehealth platforms enhance remote service proficiency, and mentorship programs empower leadership competencies. Conclusion: This study underscores the pivotal role of innovation in shaping adept nursing administrators. Integration of innovative approaches equips healthcare leaders with holistic perspectives, adaptable skills, and technological readiness. As healthcare systems evolve, these approaches offer promise for addressing challenges effectively. Innovative Contribution: By delving into cutting-edge nursing administration education, this study offers insights that reshape healthcare leadership. It bridges theory and practice, equipping future administrators to navigate the dynamic healthcare landscape

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors

New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15

Decoration of carbohydrate nanocomposite with silver nanoparticles for highly efficient adsorption of methylene blue and antimicrobial against human pathogens

The current study aims to prepare carbohydrate nanocomposite based on 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized cellulose nanofibers (CNFs) /chitosan chloride (Ch) decorated with silver nanoparticles (Ag-NPs) and designed as (TEMPO/CNF/Ch/Ag-NPs) that was investigated as antimicrobial materials and applied as efficient sorbent. CNF was prepared from cellulose through TEMPO oxidation-mechanical defibrillation technique. Anionic CNF and Ch were ironically interacted to prepare novel sustainable ionic nanofibers films. Ag-NPs having approximately 20 nm were prepared in situ to decorate the ionic fibers. The effects of experimental parameters including media pH (3.0–8.0), contact time (10–120 min), and initial methylene blue (MB) concentration (50–800 ppm) on the adsorption behavior of MB onto nanocomposite films were evaluated. The results exhibited similar and fast adsorption kinetic, as illustrated by the pseudo-second-order model. The adsorption results were best suited by the Langmuir isotherm model, and the maximum adsorption capacity for the TEMPO/CNF/Ch and TEMPO/CNF/Ch/Ag-NPs nanocomposite was 369 and 432 mg/g, respectively, at the optimized media pH of 7 with a contact time of 60 min at 88 to 90 mg/g of MB. In kinetic studies, the pseudo-second-order model for nanocomposite films provided the best fit (R 2  = 0.98), than pseudo-first-order model (R 2  = 0.82 and 0.77). The TEMPO/CNF/Ch and TEMPO/CNF/Ch/Ag-NPs nanocomposite retains 73 and 69% of its initial adsorption performance towards MB after five consecutive runs. The formed nanocomposite showed excellent efficacy against Escherichia coli (14.3 ± 0.57 mm), followed by Candida albicans (12 ± 1 mm), Staphylococcus aureus (11.3 ± 1.15 mm), and Streptococcus mutans (10.6 ± 1.15 mm), and their antimicrobial activity was enhanced by the incorporation of Ag-NPs. The formed nanocomposite might find applications in industrial and biomedical fields

Measuring Empathy among Dental Students and Interns: A Cross-Sectional Study from Dammam, Saudi Arabia

Objective. To evaluate empathy and its related factors among undergraduate dental students and interns enrolled in a public dental college in Dammam, Saudi Arabia. Materials and Methods. This cross-sectional study used the Jefferson Scale of Empathy-Health Profession Students (JSE-HPS) version to determine empathy in 362 dental students and interns in Dammam, Saudi Arabia. The JSE-HPS is a 20-item 7-point Likert scale questionnaire, and its score ranges from 20 to 140 with high values indicating increased empathy. Influences of age, gender, class year, previous year’s grade point average (GPA), educational attainment of parents, and monthly family income on empathy were evaluated. Results. Of 501 enrolled students and interns, 362 returned completed questionnaires, and the response rate of the study was 72%. The sample’s empathy score (JSPE-HPS scale) ranged from 70 to 129 with a mean of 96.75 (±13.76). Most participants believed that empathy is important for effective communication with patients (96.1%) and can improve the provider-patient relationship (95.6%). Females demonstrated a significantly higher mean empathy score (99.98 ± 14.01) than males (92.72 ± 12.35) (P<0.001). Similarly, the participants with high GPA (98.06 ± 13.69) had significantly greater mean empathy scores than those with low GPA (94.84 ± 13.68) (P=0.029). The mean empathy score increased significantly from junior students (3rd and 4th year students) to senior students (5th and 6th year students) and interns (P=0.008). Multiple linear regression analysis showed that class year (B = 2.03, P=0.006) and GPA (B = 8.67, P=0.003) were significant factors associated with empathy. Conclusions. Empathy is important for effective patient communication and improved provider-patient relationship. Female gender, high GPA, and class years were associated with empathy. Empathy should be integrated into dental curricula for effective student learning and positive patient care outcomes